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KMID : 0613820090190040532
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Journal of Life Science
2009 Volume.19 No. 4 p.532 ~ p.537
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Effect of N-Methyl-D-Aspartate Glutamate Receptor Antagonist, Memantine, on Alcohol Intake in C57BL/6 Mice
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Kim Hyun-Kyung
Kim Ho-Chan
Kim Sung-Gon
Kim Ji-Hoon
Shin Su-Mi
Lee Sang-Shin
Bae So-Hyun
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Abstract
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Previous studies reported that the N-methyl-D-aspartate (NMDA) receptor is related to alcohol dependence in terms of developing withdrawal or tolerance, however, it is controversial whether NMDA receptor antagonists are effective in preventing relapse in alcohol-dependent patients or not. The purpose of this study was to investigate the effect of memantine, an NMDA receptor antagonist, on alcohol intake in C57BL/6 mice, which prefer drinking hereditarily. Using limited access procedures in C57BL/6 mice in the state of alcohol dependence, vehicle, naltrexone 1.0 ㎎/㎏ or, memantine 5, 25, or 50 ㎎/㎏ i.p. was administered respectively for twelve days. Medication effects on 2-hours alcohol, 22-hour water, and 24-hour food intake and body weight were studied. Using repeated measure ANOVA, the naltrexone 1 ㎎/㎏, memantine 5, 25, or 50 ㎎/㎏, and vehicle groups showed significant medication by day interaction (naltrexone, df=4, F=11.827, p＜0.01, memantine 5 mg/kg, df=4, F=7.999, p＜0.01; memantine 25 ㎎/㎏, df=4, F=6.199, p＜0.05; memantine 50 mg/kg, df=4, F=10.522, p＜0.01) in 2-hour alcohol intake. In 3 memantine groups, there was no significant medication by day interaction with the vehicle group in 22-hour water intake, 24-hour food intake, or body weight. The naltrexone and vehicle groups showed significant medication by day interaction in body weight, but not in 22-hour water or 24-hour food intake. From these results, it is suggested that memantine treatment can affect alcohol intake in mice. Therefore, it is possible that a pure NMDA receptor antagonist is effective in preventing relapse in alcohol-dependent patients.
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KEYWORD
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Memantine, NMDA receptor, alcohol intake, C57BL/6 mice
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